• RNAi [he/him]@hexbear.net
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        11 months ago

        Cuz an automatic system plants cells have where if there’s something producing a LOT of RNA inside the cell, especially a lot of the exact same RNA, the cell say “this gotta be a virus”, so it takes a copy/negative of that hypercopied-RNA and use that to recognize all the copies and destroys them before they get translated or whatever that RNA does (some RNA is translated into proteins, some control the expression of other genes, some is viral genome, some are ribozymes, it doesn’t matter).

        Oh, also, besides destroying the RNA copies, the plant cell can also find where the fuck is the DNA from where all those copies are coming and shut’s that thing down methylating the shit out of it, which renders that stretch of DNA innaccessible to the proteins that produce RNA from it. (I think sometimes there aint no DNA cuz it can be an RNA virus which produces RNA copies from RNA as template but it’s a very tiny percent of cases OK? )

        So yes, it’s bassically plant adaptative “immune system”

        Anyways, you don’t need several copies of a gene for the plant to silence it, but just a strong promoter (the part of the gene that tells the plant when, where, and how much the gene should express ie make RNA copies of it). Plant virus have strong promoters. So that’s what people used to use when making transgenic plants, but oops sometimes the plant had the transgene yet it didn’t express, turns out thanks to RNAis

  • WhatDoYouMeanPodcast [comrade/them]@hexbear.net
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    11 months ago

    During my time getting an advanced degree I spent a lot of time learning about RNA and that contributed to COVID discourse being so disconcerting. It wasn’t my first time learning about RNA vaccines, I worked with human applications of Ivermectin, and I even looked at an old textbook that had a chapter about coronaviruses and fears about possible mutations.

    I learned about cool shit like interfering RNA (RNAi) and how you need RNAi to have proper growth of hands in the womb. There was this theory that DNA and protein are just convenient ways for RNA to express itself. There was this theory about “the RNA World” that was the original self-replicating nucleic acid. I learned that only ~2% of the human genome accounts for protein translation and some of it encodes RNA and we (aren’t/weren’t) sure what they were for. That section was really cool. It was kind of cool to get to the point where we were talking about viruses and RNA because it took all the building blocks that went all the way back to high school biology and physics as necessary building blocks to get to these awesome ideas about the nature of biology.

    • Wheaties [he/him]@hexbear.net
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      11 months ago

      those tend to be the best ones

      like those researchers who were cooking their insides with microwaves and didn’t realize until someone left a chocolate bar in their lab-coat pocket