I use Android Tiers, Glittertech (no surgery), and Rimatomics. My colonies always end up with just the most insane defenses with super powered androids.
Anyone who makes their way to my colony will find the most lavish place on the rim.
*We may or may not be using human hearts to till our soil.
I pretty much always use Rimefeller and my addon mod Rimefeller Research Tweaks. I also always end up with way too much food, like tens of thousands of units of food.