Only in a motorized wheelchair, at least that is what people have been charged with. Could not find an example of manual wheelchair DUI, yet article says you can in any wheeled vehicle, such as a wheelchair or bike. One of several sources for confirmation, USA. https://www.findlaw.com/legalblogs/criminal-defense/yes-you-can-get-a-dui-in-a-wheelchair/

Note: and I would imagine these people had to be visibly, obviously and arguably endangering others, I wouldn’t expect to see a cop stop someone in a motorized wheelchair randomly just to test them and charge them.