CRISPR is profoundly difficult and expensive, and gets more difficult and expensive the more chromosomes are at play. Modifying mosquitos is much easier, and with the short generations (days or weeks instead of decades for humans) it’s much easier to get the genetic changes to stick and observe their efficacy. We might get around to modifying humans someday, but it will likely be centuries before it is available for anything besides fixing lethal anomalies (and even then, it’ll be a long time until that becomes consistently successful).
As a widely available, cost-effective treatment? Almost certainly not. We have yet to successfully genetically modify a human being and there’s a metric ton of legal and ethical red tape to deal with before we can even try.
Not necessarily, but the advancement of the technology and refinement of the technique are not progressing very quickly and since it’s so far away from human application, there’s not a lot of money/investment in it.
thats not true. crispr gene therapy was just approved by the fda for sickle cell syndrome. the methods ability to change dna on living organisms is why its a big deal in the first place.
While that gene therapy does exist, it is not the same as what is being done here. The offspring of these mosquitos will have this same modified gene. The offspring of the recipients of the Sickle Cell gene therapy will not have the modified gene. We have the ability to alter a single human for their lifespan, but we do not have the ability to alter a human in such a way that their offspring will carry the same modification.
CRISPR is profoundly difficult and expensive, and gets more difficult and expensive the more chromosomes are at play. Modifying mosquitos is much easier, and with the short generations (days or weeks instead of decades for humans) it’s much easier to get the genetic changes to stick and observe their efficacy. We might get around to modifying humans someday, but it will likely be centuries before it is available for anything besides fixing lethal anomalies (and even then, it’ll be a long time until that becomes consistently successful).
i have the impression we could be there in several decades, not centuries?
As a widely available, cost-effective treatment? Almost certainly not. We have yet to successfully genetically modify a human being and there’s a metric ton of legal and ethical red tape to deal with before we can even try.
red tape doesnt take centuries to cut
Not necessarily, but the advancement of the technology and refinement of the technique are not progressing very quickly and since it’s so far away from human application, there’s not a lot of money/investment in it.
there are clinical trials for gene therapy right now.
i can see arguing that it isnt close, because it doesnt look close, but id bet it will come in decades rather than centuries.
Gene therapy is not the same thing as CRISPR. CRISPR is modifying the genome before the organism makes it past 1 cell.
thats not true. crispr gene therapy was just approved by the fda for sickle cell syndrome. the methods ability to change dna on living organisms is why its a big deal in the first place.
one can easily look this up.
While that gene therapy does exist, it is not the same as what is being done here. The offspring of these mosquitos will have this same modified gene. The offspring of the recipients of the Sickle Cell gene therapy will not have the modified gene. We have the ability to alter a single human for their lifespan, but we do not have the ability to alter a human in such a way that their offspring will carry the same modification.