All I can tell you is GSK3 is a regulatory enzyme that’s involved in gene expression (people have a higher tendency for bipolar disorder if it’s inactive). IIRC it also helps to activate/inactivate Glycogen Synthase (which inactivates/activates Phosphorylase) when people are at rest/moving (respectively).

Glycogen is a sugar molecule that muscles use to store energy; glycogen synthase creates it and phosphorylase breaks it down to glucose which is released into the blood. It wouldn’t be good to have both of them active at the same time, so there’s probably tens of kilograms of protein (enzymes) in ones body that makes sure that it doesn’t happen and GSK-3α/β are parts of that system.

A consensus sequence is a DNA thing that I’m not too familiar with yet but to have consensus means tho amino acid residues you’ve found match your target, whatever it is, I think? ¯\_(ツ)_/¯

Also all enzymes are made of a specific sequence of amino acids (like a really long string of anal beads that each have different shapes and some of the beads stick to each other which is what is meant by “Protein Folding”) which is basically what DNA is for. Too ‘phospohorylate’ an enzyme is to change it’s shape or block a substrate (a sequence of amino acids that other things attach too).

Ofc some of this might be wrong or a victim of oversimplification, but now you know that we’re all anal beads.

HAAAAANNNKK!!! HAAAANNNKK!!

YOU HAVE TO CONSIDER THAT GLYCOGEN SYNTHASE KINASE 3 PHOSPHORYLATED AT ITS N-TERMINAL SERINE (Ser-21 for GSK-3α, Ser-9 for GSK-3β) IS STILL ABLE TO ACTIVELY PHOSPHORYLATE IT’S NON-PRIMED SUBSTRATES! READ SUZUKI ET AL 2013, HAAAAAANNNKKKK!!! YOUR PUTATIVE TARGET SITE IS NOT A (S/T)-X-X-X-(S/T) CONSENSUS SEQUENCE, YOU