Can be from any kind of media.
For me it’s Margot from The Magicians (which is interesting because in the books she is anything but) and Jesse Faden from Control.
Lana ″LANAAAAAAAAAA″ Kane from Archer
Alt: Where in the world is Carmen Sandiego?
Granny Weatherwax
To me, this is one of the most fully realized female characters in science fiction (at least):
Can’t believe price Leia hasn’t been mentioned yet.
“What the hell are you doing?” “Somebody has to save our skins. Into the garbage chute flyboy!”
Lol
Captain Janeway
Sarah Connor
Risa Hawkeye from Fullmetal Alchemist
Xena
For me, Commander Ivanova from Babylon 5. Like the rest of the characters, she wasn’t perfect, but she was so strong.
Ellen Ripley. She will wreck your shit and yeet you into space.
Someone already said Susannah Dean so I’m gonna go with Roz from Frasier
The bride from kill bill.
So the absolute first that comes to mind is a joke answer: Strong Woman, the vice Principal from South Park.
The actual answer is Phryne Fisher
Buffy. I was the right age (or maybe a bit too young) when it aired and it was the first female-led show that I fell in love with.