The world's first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The world’s first human trial of a drug that can regenerate teeth will begin in a few months, less than a year on from news of its success in animals. This paves the way for the medicine to be commercially available as early as 2030.

The trial, which will take place at Kyoto University Hospital from September to August 2025, will treat 30 males aged 30-64 who are missing at least one molar. The intravenous treatment will be tested for its efficacy on human dentition, after it successfully grew new teeth in ferret and mouse models with no significant side effects.

“We want to do something to help those who are suffering from tooth loss or absence,” said lead researcher Katsu Takahashi, head of dentistry and oral surgery at Kitano Hospital. “While there has been no treatment to date providing a permanent cure, we feel that people’s expectations for tooth growth are high.”

Following this 11-month first stage, the researchers will then trial the drug on patients aged 2-7 who are missing at least four teeth due to congenital tooth deficiency, which is estimated to affect 1% of people. The team is recruiting for this Phase IIa trial now.

  • ripcord@lemmy.world
    33·
    1 month ago

    The vast majority of replies in this thread, and to nearly every positive post - are sadsackery.

    Differing opinions is fine. Raw, pointless pessimism as a monoculture is…not what you’re describing.

    • danc4498@lemmy.worldEnglish
      61·
      1 month ago

      Vast majority, eh? How do you define vast majority? The vast majority of comments in this thread are positive. You’ve decided to focus on the negative comment.

      Raw pointless pessimism? Way to totally ignore the VALID point I brought up in my comment. Insurance (including dental insurance), is bananas in America.