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Before the blast in Arlington, Virginia, police said someone from inside the house had fired shots as officers tried to enter.
Police said earlier they had responded to reports of someone firing a flare gun from a residence on Monday night.
Officers on the scene reported only minor injuries.
But it is not clear if the suspect was injured or apprehended.
Some residents in the surrounding area said on social media they felt their homes shake.
You’d have build up gas for an entire day to get an explosion like that. It’s either rigged or he had a crazy amount of explosives that he accidentally set off.